Plenary Session

Longevity Episode 2 - Nutrition science by Plenary Session

Longevity Lecture series Introduction and Lecture 1 by Plenary Session

Back to basics as I break down a trial

I discuss the CIA admitting that COVID was a lab leak; Fauci's pardon; NIH meetings; RFK Jr's Senate confirmation hearing; and more.

I'm talking about USAID and Elon's team of six engineers; the Bobby Kennedy Jr hearings, particularly concerning Samoa; MMR vaccines; DEI; and NIH funding complaints.

I discuss RFK Jr.'s confirmation as the US Secretary of Health and Human Services; recent layoffs at the CDC and NIH; and some comments by Harold Varmus in criticism of Jay Bhattacharya.

I discuss the intense media coverage of Trump and the recent decision to cap indirect costs of NIH grants at 15%.

I discuss the recent reduction in indirect funds for NIH grants and lay out why the NIH is a broken funding system.

I discuss Trump's big health care changes: NIH study sections, the MMWR gag order, the US withdrawal from WHO, and more!

The entire healthcare system is broken, it's not just health insurance companies.

Is alcohol healthy for you? I break down everything you need to know about beer, wine, and spirits.

Our 2 hour critical appraisal and ASH review. SO many guest stars

Lecture on systematic review, given by Vinay Prasad MD MPH to students in the UCSF Training in Clinical Research Program, November 2024.

Timothee Olivier and I discuss the top ESMO 2024 abstracts!

AI in healthcare - my latest keynote address

"Masking Mistakes: Lessons from the Science, Policy, and Coverage of COVID-19", the 2024 Brian Shields Lecture on Institutional Ethics which took place on Monday, October 7, 2024 for the Emory Center for Ethics. A conversation with Carlos Del Rio, MD and Vinay Prasad, MD MPH with moderation by Gerard Vong, DPhil, Director of the MA in Bioethics program.

Screening/ Drug efficacy/ Sotorasib/ Adaura and more

My UCSF lecture on driver mutation lung cancer

We break down the best studies from ASCO

Critical Appraisal - My 2 hour ASCO lecture - Day 2 version by Plenary Session

What you need to know in advance of ASCO

Should trials have carbon footprint as an endpoint?

My grand rounds; Beta blockers post MI Single center vs multicenter RCT Masks Boosters and more

I crossover SM podcast; Harvard med students video, Justice curriculum, Masking half the year

Patient advocates, Pharma funding, and is MRD a suitable endpoint

5 reasons that is a bad idea

Another flawed quality metric. Reviewing the NEJM paper "Beta-Blockers After Myocardial Infarction and Preserved Ejection Fraction".

They are s****y

Another flawed study Keynote 564. Pembro in adjuvant RCC

What happens when doctors run unethical studies?

Does car T cause secondary AML? We discuss

We talk about 2023 cancer trials

Goodman and I discuss ash updates. My myeloma talk https://www.youtube.com/watch?v=jAz84yCnfjQ

Subscribe to Sensible Med Pod; This is x over Post partum depression, orbita 2 and physics vs medicine

My Lecture in Curacao 4/4 Vaccines, Masks, Mandates, Lockdowns, School closure Other lectures to come

Entresto, Lung Transplants, How to Keep Up with Literature - Lecture to Trainees in Curacao

This is a lecture I gave on November 5, 2023, to pre-medicine undergraduate students at University of California Berkeley.

Radiation oncology in GI malignancy (endpoints and stratification) in the JCO

Prasad is back in Hawaii to give another keynote (good thing they cancelled Dallas not Honolulu). I discuss coffee and colon cancer, and censoring, and Lu177 PSMA

This is a lecture I gave on ethics and institutional review boards in Denmark in September 2023. It is the last of the three lectures I gave.

Mandrola, Prasad and Cifu are back to discuss the latest drama

This is a lecture I gave on the state of immunotherapy in oncology at the Immunotherapy Symposium In Denmark in September 2023. It is the second of three lectures I gave.

The first of the three lectures I gave in Denmark in September 2023 was on the medical evidence behind decision-making by health technology assessment groups.

This is the live recording of a talk given on the great and crazy things we do in medicine, from cancer drugs to boosters and more.

Timothee is back to discuss Malignant and Solutions

A far reaching discussion btw Mandrola and Prasad on RCTs, Coumadin, ECMO and RCTs for covid shots

Simultaneously released on Sensible Medicine. Time to subscribe to Sensible Medicine substack and podcast.

Placebo/ Journal Errors/ Cancer Screening w/ Mandrola - SM crossover

A sensible medicine crossover episode Follow the sensible medicine podcast feed for more of these discussions

T. Olivier from Geneva is back. A fan favorite guest. We discuss 3 recent papers.

Researchers were too busy counting dead bodies to give the control arm appropriate therapy when their cancer recurred. Disgusting conduct. I break down ADAURA

Mike Putman, Todd C. Lee, John Mandrola and I debate the recent JAMA paper on RCT Duplicate. This is a spirited round table discussion on the limitations of observational data. If you are reading this, leave a comment as a review!

Early treatment of myeloma, dual vs. single maintenance, and finally transplant or no transplant.

Why the USPSTF is wrong

Cost of Cancer drugs - VP's lecture

I combine two latest tracks on interpreting medical studies, medical boards, 7 doses of vaccine, and finally Walensky. Stay tuned.

We explore the fight btw NYTimes, Cochrane, and the last people keeping EBM alive

Zeb joins me for the 7th time to discuss all the key pandemic questions

My lecture to Harvard regulatory science

VP goes to Denmark to give the keynote at the Danish medical association conference

What is science?

Karmma 3 discussion; then Sensible Medicine on Long COVID, 4th year fellowships and more; Then my breakdown of FDA's NEJM Letter to the Editor

I get into endpoints, surrogates, validation, blinding, crossover, and control arms.

I talk RCTs 101; KM Plots; Blinding: 2:1 randomization: Concealment and more. Then Papa Heme Tells you How to Find your First Job

Dr. Tom Newman UCSF Emeritus Professor & Superb teacher discusses VP's recent Public Health Videos. The two don't fully agree, but the discussion is worth your time.

Mike Putman, asst prof. EBM Rhematologist debates me on value of boosters, observational studies and more.

A new podcast feed called Sensible Medicine is up; here is a sample of what we have to offer

I destroy the trial. Bad control arm. Informative Censoring. No OS gain. Authors DOWNPOWERED TRIAL. Fishy PFS. Fishy HRQoL. This trial should be in trash can.

I annotate an online case discussion; Every decision is not based in evidence. Madness

This lecture on Burnout will not be like any other you have heard

I break down the GEM CESAR trial K, R, D, Pom, Dara, Dex, R, and Auto and all before you actually have cancer What a crazy trial!

This uncontrolled trial of Dara-KRD claims to be looking for cure; Unfortunately, the PI has not thought through what that would look like, and accordingly all the claims are incorrect. Moreover the primary endpt is negative. Sad day for oncology

Sample size games, primary endpoint, head to head trials in oncology Rate this podcast on itunes Coming next is Triangle trial

Grand rounds on heme and heme malignancies given 12/16 at University of Southern California (some parts removed) More ASH coming soon

Is it acceptable to take someone with myeloma who has gotten just 2 regimens and put them on a phase 1? VP says hell no.

In this lecture given December 7, 2022, I cover 5 things: Vaccines Masking Long COVID Schools/Immunity Debt Paxlovid

Should we treat smoldering MM, a debate Long COVID vs Long URI Review the show; Say Hi at ASH22

Smart Start is a useless lymphoma study; We have to stop putting our careers ahead of patients. In the second part, I discuss the 'experts' featured on STAT. Wowzers. I will be at ask. Hit me up: [email protected]

I am joined by Cornell Professor Paul Fenyves; a practicing internist Dr. Fenyves walks us through COVID19 policy. We will be back soon with more cancer medicine. Including a devastating lymphoma one.

I was invited to give this talk to a UK conference on Myeloma Please LEAVE A REVIEW of this podcast

Lecture I gave this weekend in Hawaii to the Medical Oncology Association; One of the best audiences I've had

I give Grand Rounds to UCSF Neurosurgery on how to read and interpret Neurosurgery Studies (Video and slides coming soon to YouTube) Also I discuss Bob Califf's Promotion of Paxlovid

Learning Loss is Devastating; Here are the data and what it means

Learn about UCSF Hematology Oncology Program with Dr. Gerald Hsu, MD PhD Malignant Heme and Program Director

A new study from Switzerland confirms the rate of subclinical myocarditis

LONG COVID, Vaccines, Paxlovid and More

discuss NordICC with the trial PI Power calc specified 50% non-adherence ADR is on par with US studies from the time Colo quality good Perf rate lower than US! How does he counsel individuals & governments What he thinks of USPSTF

A double standard to condemn data with limitations, based on political party, will destroy medicine. We will back to oncology soon, but this is important

Cifu, Mandrola and Prasad fight about colonoscopy

I break down the history and data for the first ever randomized trial of colonoscopy, appearing in NEJM on Oct 9, 2022

Polo Javelin 100 bladder Crossover Control arms How to read and keep up with the literature

Invited Lecture to Cancer Center Directors

I travel to UCSD to interview Dr. Goodman about myeloma, celebrity oncology culture, his career, education, patient care, choosing a specialty and more.

Based on listener questions, I discuss how to apply for and get your first job.

T.O. joins me for the missing episode. These are the unspoken rules of Oncology; We dive deeper into Malignant Book Club.

Timothee Olivier joins me for the 7th installment of our book-club We cover famous trials in oncology

How do careers vary between the academy and industry? We have a panel of the best: Sanam Loghavi from MD Anderson, Aaron Goodman UCSD, and David Steensma Novartis (formerly Farber/ Mayo) and VP #Real talk

Timothee Olivier joinrs me as we explore part 3 of the book Crossover, sample size, observational vs RCTs

Adam Cifu is here to discuss clinical excellence and his new podcast

T.O. joins me to grill me on the rest of Financial Conflict of Interest and Precision Oncology. We discuss the need for randomization, and when it can be omitted. A must listen for Oncology Fans.

VP discusses the LaceWing study in Blood. A Phase 3 RCT of GILT AZA vs AZA; Medical writers; confounding; table 1; balance; and so much more

Timothee Olivier joins me to discuss recent papers: IMPOWER10 Checkmate 816 Path CR/ EFS/ Surrogates Drug Dosing, cGCSF rules and more Bread and butter oncology

The POLO trial, which we first broke on PS Season 1- is back with null OS results. But the trial authors enter the spin cycle. VP goes line by line.

VP explains H index, total cites, papers, US News and World Report rankings and how evaluates researchers and doctors.

VP addresses what to do you if you get an idea from listening to the show, and deconstructs ECHELON-1. Instead of listening we highly recommend you watch the video on YouTube with graphics. This is worth the watch.

How to think about when and how to do RCTs? What are the limitations to observational studies? Smoking. Parachutes. Dostarlimab. Guarantee Time Bias. Confounding. Multiple Hypothesis testing and more

I make the case why this podcast should be your go to for Med, Onc & Policy. I describe my philosophy of Evidence, Empiricism, and show how this connects to many oncology studies. I answer a bunch of Listener Questions

How to read randomized trials in cancer medicine. Phase 2 vs 3, control arm, crossover, post protocol, censoring (the basics), and how law professors and medical professors are different and why it matters.

Lies and Exaggerations about Kids Vaccine I give examples, and show why they are lies

What happens when you treat people with $168,000 a year medicine when most of them will never need treatment, and all of them don't need treatment now

I take a deep dive into the data for the mRNA vaccines for kids under 5 years olds

I sit down with H Jack West. City of Hope. Thoracic Oncology and we have a long discussion about trials; staging; PDL1 thresholds; Driver mutations and post protocol care; ADAURA; Adjuvant; & More

I discuss the timeline of Ratify and Quantum. Was this an ethical trial? Is it sufficient to say a trial is ethical because 50% of participants get something?

The drug has a high response rate and lots of infections, is it active? Yes; Efficacious? ???? I review ASCO2022 updates

Are the results from Luis Diaz as good as touted. What trial should they do going forward? A 100% CR rate in Stage II and III rectal cancer??

My take on the standing ovation for DESTINY Breast 04 Traztuzumab Deruxtecan vs. Investigator choice after endocrine therapy and 1 or 2 chemotherapies for HER2 low

I break down Richardson, et al. NEJM DETERMINATION Transplanters are determined to keep going, should they be? Watch the videos b/c I have lots of great visuals My ASCO Coverage continues

The second paper from #ASCO2022 #ASCO22 that I break down This is one of the most technical papers I breakdown on the channel CT DNA used to omit chemo in Stage II colon cancer Read the book Malignant if you learn from this Watch the YouTube Figures https://youtu.be/QxOBIi7I2BU

Continuous vs. Fixed, 3 vs 2, PFS is the primary endpoint No OS Bad crossover Lots to discuss here I will be covering all the major ASCO papers on @PlenarySession Subscribe to my substack https://vinayprasadmdmph.substack.com/

I am joined by Dr. Katie Sharff, infectious disease doc, to discuss two of her papers on myocarditis after COVID-19 vaccination. https://doi.org/10.1016/j.amjcard.2022.02.039 https://doi.org/10.1101/2021.12.21.21268209

I get back to my roots; I explain surrogate validation and a new JCO paper from the FDA authors on EFS and OS in AML. You won't want to miss it

In this episode I dissect a test negative case control trial; I talk about a famous pancreas cancer study and I revisit the failure of Myeloma trialists

I am joined by Manni Mohyuddin to talk about How I treat frontline transplant eligible myeloma. Vinay Prasad makes the case the entire field of myeloma is corrupt and broken.

I join Dr. Bienen in person to discuss COVID19 and failures in public health

ID ethicist, and brilliant COVID19 commenter

This is a compilation of the last week and half of monologues by VP on his Youtube Channel about COVID19 policy

I talk to UCSF Professor Eric Collison about his lab, grant writing, the physician scientist life, cancer, and a doctors duty.

A brilliant talk by one of the most brilliant scientists alive; JPAI lectures VKPrasad lab on all things COVID19; When does the pandemic end? What are the lessons?

Listen in as I give an unscripted lecture to a general audience about COVID-19; What we got right and wrong these last 2+ years.

Kristina Jenei becomes the 4th guest host and flips the tables on me, interviewing me about academic medicine and more...

I perform an analysis of the AGILE trial that came out in NEJM today; I find 6 huge problems. Follow PS on twitter; and write to us to let us know what you think

Timothee Olivier joins me for the 3rd of 9 parts of the Malignant book club - this covers all of Oncology

Pragmatic vs Ideal, Surrogate vs. Hard Endpoints; Time it takes; Ethics; Control arms; Purpose; I cover it all here.

In this book club we discuss Chapters 2 and 3 of Malignant, covering Surrogates and their role in Oncology

This is a brief monologue with Dr. Timothee Olivier, and the audio from a class I taught on RCTs-- when are they needed in biomedicine

Here is the first of a 9 part series on Malignant Book Club with Timothee Olivier from Switzerland We cover cost of drugs, and intro to cancer drug policy

I lecture on basics on cancer drug policy

I am back with Timothee Olivier from Geneva Switzerland to discuss Part 2 of our laboratory work. Can oncologists criticize RCTs? We also announce our new series. A 9 week Malignant Bookclub

Timothee Olivier from Geneva Hospital Switzerland joins me for the first in a series of episodes on updates from VKPrasad laboratory, where we discuss cancer drugs & policy & evidence

Jacob Hale Russell is back from Rutgers law to talk about his new piece in Tablet Magazine.

A discussion about the excesses of testing with Gil Welch

I am joined for my 4th conversation with Zeb. This is a far reaching conversation where we discuss mandates, vaccines, masking, and why evidence based medicine still has something to offer.

We're back this week with a collection of monologues! We talk about a Paul Offitt quote, COVID boosters for adults and kids, COVID testing, whether this is a pandemic of the unvaccinated, myocarditis and pericarditis, college campus restrictions, and more! STAT News Op-Ed: https://www.statnews.com/2021/12/23/at-a-time-when-the-u-s-needed-covid-19-dialogue-between-scientists-francis-collins-moved-to-shut-it-down/ Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have a short discussion for you of the MEMOIR study, published in The Lancet Oncology: "Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study". We also have a special treat for you: a lecture Dr. Chris Booth of Queen's University, Kingston, Ontario, Canada recently gave titled "The Emperor Has No Clothes", a critique of the current state of cancer care. MEMOIR: doi.org/10.1016/S1470-2045(21)00546-5 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have an in-depth, in-person interview with Dr. John Ioannidis of Stanford University. We ask him: where are we now with COVID-19? Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back again! We discuss Omicron, travel bans, masks, vaccine mandates, and more. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

David Russler-Germain and Papa Heme join VP to discuss the hottest ASH lymphoma papers: POLARIX and 2 CAR-T trials (ZUMA-7 & BELINDA) Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have an in-person interview for you today! We sit down with Dr. Adil Daud of UCSF to talk all things melanoma. We cover Tebentafusp, nodal dissection, the Will Rogers phenomenon and the effect of stage migration on clinical trials as imaging advances, adjuvant vs I/O, academic training vs apprenticeship for budding oncologists, and more! Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We're back with a hematology/oncology heavy episode! We talk about oral azacitidine for acute myeloid leukemia (AML) and nelarabine for T-cell acute lymphoblastic leukemia (T-ALL) with Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology and Associate Professor at University of Michigan Medicine. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we interview Dr. Bill Hall, Associate Professor of Radiation Oncology and Surgery at Medical College of Wisconsin, on his new paper out now in the Journal of Clinical Oncology titled "Value of Neoadjuvant Radiation Therapy in the Management of Pancreatic Adenocarcinoma". Neoadjuvant: doi.org/10.1200/JCO.21.01220 Back us on Patreon! www.patreon.com/plenarysession

Today we interview Dr. Cody Meissner, Chief of the Division of Pediatric Infectious Disease and Professor of Pediatrics at Tufts University School of Medicine. Dr. Meissner is also a member of the US FDA Vaccine Advisory Committee. We talk about the affect of school closures on the health of children, the evidence base for COVID vaccine mandates in children, and the nuance surrounding all of it. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back by popular demand! We talk about the failures, both scientific and ethical, of the COVID-19 pandemic. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We're joined today by Dr. Aaron Goodman, a hematologist/oncologist at the University of California San Diego, to talk about calling out an unethical clinical trial, Melflufen, and academic oncology. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We're joined by Dr. Bapu Jena of Harvard Medical School to talk about his show, Freakonomics, M.D., and his career at the intersection of economics and medicine. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have three topics for you today: We talk about our recent paper on the use of second-line immunotherapy in kidney cancer, the controversy over whether a cancer clinical trial was unethical, and the results of the randomized clinical trial CASSIOPEIA. Kidney Cancer: doi.org/10.1001/jamanetworkopen.2021.24728 CASSIOPEIA doi.org/10.1016/S1470-2045(21)00428-9 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have an interview with Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford. We talk about COVID-19 health policy and where we went wrong, speaking specifically from the values framework of health, fairness, and freedom. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have a summary of our thoughts for you on recent news about COVID. We discuss the prospect of FDA authorization of a Moderna booster, 8 lessons for health policy in times of crisis, updates on myocarditis data from Israel and Europe, how our experiences with COVID warn us of the possible end to democracy, how progressivism is dead, why social media should not censor views, the CDC's new masking studies, the slogan "follow the science", weekly testing of vaccinated college students who don't have symptoms, the survival of science after COVID, and the question of requiring a booster to follow the Johnson & Johnson vaccine. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode we're joined by a number of special guests: Dr. Christopher Booth and Dr. Adam Fundytus of Queen's University in Kingston, Ontario, Dr. Manju Sengar of the Tata Memorial Centre, and Dr. Aaron Goodman of the University of California at San Diego. We talk about their new papers: "Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey", "Practicing on the edge of oncology: when standard of care feels uncomfortable", and "Has the Current Oncology Value Paradigm Forgotten Patients’ Time? Too Little of a Good Thing". Cancer Medicines: doi.org/10.1016/S1470-2045(21)00463-0 Edge of Oncology: doi.org/10.1038/s41571-021-00550-9 Value Paradigm: doi.org/10.1001/jamaoncol.2021.3600 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, in honor of him and in recognition of his passing, we have an old interview with Dr. Elihu Estey of the University of Washington on his 40 years of experience as an oncologist, the "Renaissance" of drugs for leukemia, and advice for trainees on how to approach career goals. This interview originally aired as episode 1.49. He will be missed.

This week we take a break from #zercovid to give you another episode that's a deep dive into COVID-19. We start with an interview with epidemiologist and infectious disease expert Dr. Daniel Morgan of the University of Maryland School of Medicine; we talk about cognitive errors in medical decision-making and how it relates to COVID-19 health policy. After that, we have a series of thoughts for you on COVID vaccine mandates for schools, President Biden's vaccine plan, the FDA's vote on boosters, John Ioannidis' new paper on vaccinating students, the Pfizer results for vaccines in kids 5-11, and accepting that COVID is here to stay. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we take a brief break from our #zerocovid mantra to offer you our thoughts on current events. We cover a variety of topics, including: medical doctors in academia, cancelling conferences even for the vaccinated, masking 2-year-olds, equipoise, the CDC Georgia study, myocarditis, booster shots, outdoor masking at Duke, no more zero COVID in Australia, the Bangladesh cluster RCT on masks and its implications for kids in the USA, the resignation of two senior FDA officials, LA schools mandating vaccines, vaccinating college students, and more. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today's episode is a lecture our host, Dr. Vinay Prasad of University of California San Francisco, gave recently on censoring patients in Kaplan-Meier plots. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we're joined by social epidemiologist, Dr. Maria Glymour of UCSF. We talk about her work in studying public health interventions for dementia and how her experience in academia has led to her conviction in the necessity of rigorous, quantitative technical skills training for epidemiology PhD students. We touch on how to have a good idea, her advice for PhD applicants, and working in a soft money (grants) vs hard money environment. Finally, we discuss her idea for a stepped-wedge trial approach to evaluate the new Alzheimer's drug, aducanumab. Aducanumab: https://sites.bu.edu/melodem/files/2021/07/Pragmatic-Study-Designs-to-Accelerate-Aducanumab-Evidence_Glymour.pdf Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have two oncology conversations for you today. The first is with Dr. Saroj Niraula of the University of Manitoba, and together we discuss the necessity of randomized controlled trials for granting FDA approval of cancer drugs. The second is with Dr. Ghulam Rehman "Manni" Mohyuddin of the University of Utah on a variety of myeloma studies, including LIGHTHOUSE, OCEANS, and HORIZON. Feasibility of RCTs: doi.org/10.1093/jncics/pkab061 RR of Alternative Treatments: doi.org/10.1002/ijc.33231 Study Time Reduction: doi.org/10.1001/jamainternmed.2018.8351 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we interview Dr. Bita Fakhri of UCSF on the current research behind treatments for lymphoma. We touch on CAR-T, ABVD, DA-EPOCH-R, and more. We also talk about histiocytic disorders, Dr. Fakhri's career in academia, and learning through teaching. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we're compiling all our recent monologues on COVID-19. That's right -- we're taking a break from #zerocovid to give you an episode that's #allcovid! We cover a whole range of news and opinions covering the Delta variant. We give an evidence-based-medicine doctor's take on the question: Are RCTs necessary in the age of COVID19? We also talk about how the American Academy of Pediatrics (AAP) lost the narrative. We detail how America failed kids because the AAP, CDC, & the teachers unions all hate Trump more than they love kids. We cover vaccine boosters: are they justified? Is there enough evidence? We detail how to run a randomized controlled trial of a policy intervention. And, finally, we confront the New York Times opinion article "Actually, Wearing a Mask Can Help Your Child Learn". We confront the tough questions: Do children really need to see faces? Why do we even have faces? Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we interview Dr. Alan Venook of UCSF, a renowned expert in clinical trial design and gastrointestinal malignancies. We talk about the evolution of the treatment for colorectal cancer over the last few decades, starting with 5FU. We also discuss his time working as an editor for the Journal of Clinical Oncology and we talk about his advice for budding clinical trialists.  Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have two short thinkpieces for you. The first is on the lessons that can be learned, or have been learned along the way, from publishing 300 peer-reviewed papers in medical/scientific journals. The second is on the recent publication with Jenny Gill out now in the International Journal of Cancer, titled "After COVID-19, telemedicine may be used in addition to usual care and not in lieu of: Implications for health systems". Telemedicine: doi.org/10.1002/ijc.33752 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we interview Dr. Josee-Lyne Ethier of Queen's University in Kingston, Ontario, Canada on her new paper "Practice Patterns and Outcomes of Novel Targeted Agents for the Treatment of ERBB2-Positive Metastatic Breast Cancer", out now in JAMA Oncology. We talk about the real-world survival outcomes for pertuzumab and T-DM1, comparing these outcomes to the results of pivotal clinical trials CLEOPATRA and EMILIA. Practice Patterns and Outcomes: doi.org/10.1001/jamaoncol.2021.2140 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today's episode is a compilation of a few short monologues. We provide an oncologist's evidence-based medicine perspective on four papers: CheckMate 274, adjuvant nivolumab in urothelial cancer; PARADIGM-HF/Entresto; the POLO trial, olaparib in pancreas cancer; and the paper "An algorithmic approach to reducing unexplained pain disparities in underserved populations". CheckMate 274: doi.org/10.1056/NEJMoa2034442 PARADIGM-HF: doi.org/10.1056/nejmoa1409077 POLO: doi.org/10.1056/NEJMoa1903387 Knee pain: doi.org/10.1038/s41591-020-01192-7 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we sit down (in person!) with Dr. Jeff Bien of Stanford University to break down all the details -- from the methods to the statistical analysis to the conclusions -- of the CheckMate 649 trial, which pitted first-line nivolumab plus chemotherapy against chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma. CheckMate 649: doi.org/10.1016/S0140-6736(21)00797-2 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have two short monologues for you on recent papers. The first, by popular request, is the problems with the VISION trial, which treated metastatic castration-resistant prostate cancer with lutetium-177–PSMA-617 (Lu-177–PSMA-617) radioligand therapy and standard of care. The second is on the paper recently published in Science titled "Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients". Fecal transplant: doi.org/10.1126/science.abb5920 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

In today's quick episode, we talk about our new paper out now in JAMA Network Open titled "The Oncologic Drugs Advisory Committee Votes of April 2021—Implications for the Fate of Accelerated Approval" ODAC Votes: doi.org/10.1001/jamaoncol.2021.3046 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We have a reverse episode for you today! Emma Greenstreet, a second-year medical student at UCSF, interviews our usual host, Dr. Vinay Prasad on why and how he chose hematology/oncology as a specialty, engaging with criticism, mentorship, medical student rotations, choosing a research project, and urging doctors in academia to aim higher. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We sat down in person with Dr. Rahul Banerjee, a BMT/CAR-T fellow at UCSF, to talk about all manner of topics including CAR-T, randomized trials in oncology (and, specifically, Dr. Banerjee's two recent papers out now), social media, treating Multiple Myeloma, and how people make career decisions. What Oncologists Can Learn From COVID-19: doi.org/10.1038/s41571-020-00448-y Are Observational, Real-World Studies Suitable: doi.org/10.1001/jamanetworkopen.2020.12119 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we are joined by Dr. Ameet Sarpatwari of Harvard Medical School to discuss how so many great minds in oncology are leaving cancer research in academia for industry. We also talk about the evidence (or lack thereof) behind the recent FDA approval of aducanumab to treat Alzheimer's disease. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have a short monologue for you on just a few topics: a treatment algorithm for follicular lymphoma and our host Dr. Prasad's new paper out now in the European Journal of Clinical Investigation: "Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?" RCTs or Synthetic Control Arms?: doi.org/10.1111/eci.13580 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we're back with another real-life (non-virtual!) interview. We're joined by Dr. Nina Shah of UCSF to discuss her career and her work in mutiple myeloma as well as the complexities of advancing your career -- dealing with productivity metrics like the h-index or the Kardashian index, switching institutions, balancing work with your home life, adapting to the changing field of oncology, and more. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we sit down with Dr. George Sledge of the Stanford University Medical Center to hear the story of his career and to discuss the history of breast cancer research and treatment. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we're launching season 4 of Plenary Session! This season we're returning to our love of monologues. On today's episode we talk about highlights from the recent annual meeting of the American Society of Clinical Oncology. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, we interview Dr. Marty Makary of Johns Hopkins School of Medicine and Bloomberg School of Public Health on how he chose his path in medicine, how health care as it is in the United States needs to change, and how groupthink dominated COVID-19 health policy. We discuss a variety of topics from his research on overuse, the prevalence of burnout in healthcare professionals, silos in medicine, to patients' lawsuits against hospitals. We touch on his two books, the latter of which has a new edition coming out next month that addresses COVID-19: Unaccountable: What Hospitals Won't Tell You and How Transparency Can Revolutionize Health Care, and "The Price We Pay: What Broke American Health Care--and How to Fix It". Unaccountable: https://www.bloomsbury.com/us/unaccountable-9781608198368/ The Price We Pay: https://www.bloomsbury.com/us/the-price-we-pay-9781635575910/ Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we have a brief monologue for you on how to think about COVID-19 policy in the context of rare event and declining probabilities. We also touch on what to expect from season 4 of this podcast, as season 3 comes to an end. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today's episode is hosted by guest Logan Powell, an incoming medical student at the Texas A&M College of Medicine and creator of this podcast's show notes. He reverse interviews our usual host, Dr. Vinay Prasad, in honor of the one-year anniversary release of Dr. Prasad's book "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer". They explore a few behind-the-scenes stories. Show notes: www.plenarysessionpodcast.com Listen to Malignant with a free 30-day trial of Audible: www.audible.com/pd/B08864KFHW/?so…ACX0_195112_rh_us Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we try something new. We're joined by five esteemed multiple myeloma experts for a back-and-forth round table discussion on the disease, including initial therapy, high risk, and maintenance. Our guests are Dr. Raj Chakraborty of Columbia University, Dr. Sam Rubinstein of the University of North Carolina Chapel Hill, Dr. Manni Mohyuddin of the University of Utah, Dr. Ben Derman of the University of Chicago, and Dr. Kevin Knopf of Highland Hospital. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we bring back our popular Journal Club with a Fellow segment. We're joined by Dr. Karine Tawagi of the Oschner Clinic in Louisiana to discuss the CLEAR trial: "Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma" as published in the New England Journal of Medicine. CLEAR: doi.org/10.1056/NEJMoa2035716 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Our guest today is Dr. Joshua Briscoe of Duke University. We discuss Med-Psych (a joint internal medicine and psychiatry residency) and how it and palliative care connect to the human side to medicine: providing the care for quality of life and dignity that patients actually need, from comfortable bedding to physician-assisted suicide. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We're joined today by Dr. Aaron Goodman, a hematologist/oncologist at the University of California San Diego, to discuss diffuse large B-cell lymphoma (DLBCL). We talk about bad cancer drugs and bad Twitter users. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we sit down with Dr. Ioana Cristea of the University of Pavia, Italy and the Meta-Research Innovation Center at Stanford to discuss meta-research, reproducibility, and expertise. We also talk about our shared experiences as "early career researchers" (ECRs), also known as Early Stage Investigators, a term coined by the National Institutes of Health to describe researchers who earned their last research degree less than 10 years ago. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we host a Classical Hematology Chat on thrombosis associated with COVID-19 vaccines. We're joined by Drs. Sven Olson and Joseph Shatzel of Oregon Health & Science University as we talk about cerebral venous thrombosis (CVT) and vaccine-induced immune thrombotic thrombocytopenia (VITT). Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we are joined by Genève Campbell, scholar of democracy and government, as we discuss sociology and politics in the context of COVID-19. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we sit down with Dr. Bishal Gyawali of Queen's University in Kingston, Ontario, Canada and with Dr. Nathan Cherny of Shaare Zedek Medical Center in Jerusalem, Israel to talk about the European Society of Medical Oncology (ESMO) and the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS), which aims to improve cancer therapy decision-making. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, we sit down with Dr. Cathrine Axfors of the Meta-Research Innovation Center at Stanford (METRICS) to discuss how Sweden responded to COVID-19 and the nation's attention to what policies would be sustainable. We also touch on her paper "Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials" as well as school closures, data to support mask policies, and more! Hydroxychloroquine: doi.org/10.1038/s41467-021-22446-z Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we talk with Dr. Avi Loeb of the Harvard-Smithsonian Center for Astrophysics about astronomy and the culture of the academy, as well as diving into topics discussed in his new book Extraterrestrial: The First Sign of Intelligent Life Beyond Earth. Extraterrestrial: https://www.hmhbooks.com/shop/books/Extraterrestrial/9780358274551 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we talk with Dr. Mark Lythgoe, a Clinical Research Fellow at Imperial College London, on his new paper titled "Race reporting and diversity in US food and drug administration (FDA) registration trials for prostate cancer; 2006-2020", out now in Prostate Cancer and Prostatic Diseases. Race Reporting: doi.org/10.1038/s41391-021-00361-0 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, we invite Dr. Chris Whaley of RAND and Dr. Neeraj Sood of the USC Price School of Public Policy to discuss their new paper titled "Back to School: The Effect of School Visits During COVID-19 on COVID-19 Transmission", out now in the National Bureau of Economic Research. Back to School: doi.org/10.3386/w28645 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today our guest is Dr. Paul Edward Sax, Clinical Director of the Infectious Disease Clinic and Professor of Medicine at Harvard Medical School. We talk about all things COVID-19. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, we interview Dr. Roxana Daneshjou, a clinical scholar in dermatology and postdoctoral research fellow at Stanford University. We talk about artificial intelligence in dermatology and beyond. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

On today's episode, we have a short monologue for you on the recent CheckMate 577 study that was recently published in the New England Journal of Medicine. The title of the paper is "Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer". CheckMate 577: doi.org/10.1056/NEJMoa2032125 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we're joined by Dr. Daniel Meyers of the University of Calgary who's here to discuss his new paper out now in the Journal of Cancer Policy. It's titled "Industry payments to US physicians for cancer therapeutics: An analysis of the 2016–2018 open payments datasets". Industry payments: doi.org/10.1016/j.jcpo.2021.100283 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Today we sit down with Dr. Kirsten Bibbins-Domingo, Chair of the Department of Epidemiology and Biostatistics and the inaugural Vice Dean for Population Health and Health Equity in the UCSF School of Medicine. We talk about mentorship throughout a career, the unique value of epidemiology and biostatistics, finding passion in your work, disparities in healthcare during the COVID-19 pandemic, and more. Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew