The Wellness Roundtable

Midlife isn’t a crisis—it’s a calling. In this episode, New York Times bestselling author and Modern Elder Academy founder Chip Conley sits down with host Alexia Brue to reframe aging as a powerful phase of reinvention. Drawing from his work with Airbnb and MEA, Chip explores how emotional resilience, community, and “life literacy” can become the true metrics of a long, meaningful life. With wit and wisdom, he challenges conventional career arcs and invites listeners to consider what a purposeful second (or third) act could look like. Beth McGroarty of the Global Wellness Institute also joins the conversation to share data on the demographic shifts driving this reframing of midlife. She unpacks how aging boomers are rejecting traditional retirement, how longevity is reshaping work itself, and why we need bold new models for connection, housing, and purpose in later life. Inside this Episode: Why wisdom—not youth—may be the most undervalued longevity assetEmotional, cognitive, and social well-being as pillars of healthspanNew rites of passage: why we need a midlife curriculumThe Modern Elder Academy and the future of multi-generational livingBeth McGroarty: Rise of “Don’t-Call-It-Senior-Living” concepts like Mather, the wellness industry’s opportunity to support older workers, and the economic imperative to reimagine purpose after 60Why longevity solutions must go beyond biology to meaning, contribution, and communityResources Mentioned: Modern Elder AcademyGlobal Wellness InstituteMather InstituteHosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

What if your skincare routine could go beyond aesthetics and actually slow aging at the cellular level? In this episode of The Wellness Roundtable: Longevity, Alexia Brue sits down with Carolina Oliveira, MD / co-founder and CEO of OneSkin, a biotech company on a mission to transform skin from a cosmetic afterthought to a longevity biomarker. Dr. Oliveira shares how her team of scientists developed OS-01, the first topical peptide shown to reduce the burden of senescent cells in skin. We explore the clinical validation behind the product, why “skinspan” matters for your healthspan, and how your skin’s biological age may be a bellwether for systemic inflammation and immune health. This is not your average skincare chat—it’s a science-backed conversation about the future of personalized longevity, from barrier function to bioinformatics.  This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.  Inside This Episode:  Why skin is more than cosmetic: it’s a modifiable aging organThe role of senescent cells in driving systemic inflammationHow OneSkin developed and validated its OS-01 peptideThe surprising link between topical products and internal biomarkersWhat most longevity enthusiasts overlook about skin healthHow OneSkin is earning credibility with leaders like David Sinclair and Peter DiamandisDaily protocols: How Dr. Oliveira approaches her own longevity stackResources & Mentioned: OneSkin’s OS-01 peptideMentions: David Sinclair, Peter Diamandis, Bryan Johnson Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch Music provided by: Myndstream    Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts!

 Short Summary: Women may live longer—but they spend more of those years in poor health. In this essential conversation, Piraye Beim, MD & founder of Celmatix, reveals why ovarian aging is the hidden accelerant of female biological decline—and why extending ovarian healthspan could be the next major breakthrough in longevity science. From inflammaging to AMH biomarkers, Dr. Beim brings cutting-edge reproductive science into the center of the longevity discourse. This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.   Inside this episode: The “gonadal gap”: why menopause accelerates aging for womenWhy ovarian function is a key regulator of brain, bone, and metabolic healthHow tracking AMH levels could transform preventive care for women in their 30s and 40sThe underfunding of female longevity research—and how that’s starting to changeARPA-H and other public-private partnerships funding therapeutic innovationsThe potential to delay menopause and extend healthspan through new medical approachesResources Mentioned: Celmatix ARPA-H research on ovarian aging Global Wellness Institute Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

Short Summary:  What does a true longevity care model look like in practice—not just in theory? Alexia sits down with Robin Berzin, MD and founder and CEO of Parsley Health, the nation’s largest functional medicine and longevity clinic. A longtime force in personalized medicine, Dr. Berzin offers a rare window into how Parsley is merging diagnostics, clinical care, and innovation to shift the healthcare paradigm—from reactive to radically proactive. In this conversation, Dr. Berzin unpacks the most important—and overlooked—biomarkers for healthspan, the cultural moment that catapulted longevity into the mainstream, and why many people are chasing biohacks while ignoring the root causes of the diseases they already have. Inside this episode: The six biomarker domains that matter most—and why conventional labs fall shortWhy strength training and sauna are at the top of her own longevity listThe truth about peptides, GLP-1s, and whether rapamycin is ready for prime timeHow Parsley is using AI to scale personalization—without losing the human touchWhat women really need to know about hormone therapy, inflammation, and hidden thyroid issuesWhy she believes estrogen may be “the new longevity drug”Whether you're a clinician, a consumer, or somewhere in between, this conversation offers a grounded, data-informed look at what it really takes to extend not just lifespan, but healthspan.  Resources Mentioned: Parsley HealthDr. Robin Berzin’s NewsletterSupplement tracking app: SuppCoRobin on Instagram: @robinberzinmd Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

Short Summary: Abby Levy, co-founder of Primetime Partners and a leading longevity investor, joins Alexia Brue to break down the massive opportunity—and responsibility—facing business leaders in the age of longevity. From redefining retirement to redesigning financial services and wellness products for older consumers, Abby shares a venture capitalist’s view on where this market is headed, and how brands must evolve to meet the needs of a longer-lived population.   This episode also features insights from David Stewart, founder of the innovative high-growth media platforms of Ageist and SuperAge, and a passionate champion of the modern 50+ lifestyle.   Inside this episode: Why the “longevity economy” is one of the biggest demographic shifts of our timeHealthspan, wealthspan, and workspan: the new pillars of aging wellHow retirement is being reframed as a 30+ year life phaseInvestment trends in telemedicine, caregiving tech, and financial wellnessBridging the gap between wellness culture and precision health solutionsResources Mentioned: Primetime PartnersAgeist and Super AgeGlobal Wellness Institute – Longevity Economy ReportsHosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts!   

Short Summary: Regenerative medicine is no longer science fiction. In this deep-dive episode, Adeel Khan, MD a leader in cell therapy innovation, joins Alexia Brue to explore the science behind stem cells, gene editing, and tissue engineering. From MSCs and exosomes to the ethics of access and experimentation, Dr. Khan unpacks both the promise and the hype around the most futuristic corner of the longevity movement.  This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute, who shares her thoughts on regenerative medicine, and whether the wellness industry is ready for this level of science and the potential culture/knowledge gap that’s happening. Inside this episode: What regenerative medicine means—and how it differs from functional medicineWhy stem cells from your own body may not be the best bet after age 40The future of gene editing: CRISPR, prime editing, and cellular repairAutologous vs. allogeneic therapies: what's scalable, what's safeEquity concerns: how longevity tech could widen the health gapGlobal regulatory hurdles—and the need for new frameworks for safety and efficacyResources Mentioned: Dr. Adeel Khan’s Eterna Medicinal Practice Global Wellness InstituteHosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at globalwellnessinstitute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts!   

Short Summary: Professor and longevity expert Andrea Maier, MD, PhD, joins Alexia Brue to explore how aging is no longer a fixed destiny, but increasingly a modifiable risk factor. As co-founder of Singapore-based Chi Longevity Clinics, Dr. Maier shares how her team is translating epigenetic science, precision medicine, and behavioral coaching into scalable interventions for healthspan. From biological aging clocks to the future of annual checkups, this episode offers a pragmatic look at how medicine is slowly shifting from sick care to proactive longevity care. Inside this episode: Chronological age vs. biological age—and how to measure the differenceWhat precision geroscience looks like in practice: biomarkers, diagnostics, personalized protocolsHow Chi Longevity Clinics are operationalizing evidence-based aging interventionsCognitive health and dual-task testing as a window into biological resilienceHow insurance, medical training, and incentives must evolve to support preventionFuture vision: What your annual “healthspan check-in” could look like by 2030 Resources Mentioned: Chi Longevity Global Wellness Institute Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

Six Senses Wellness pioneer Anna Bjurstam joins Alexia Brue for a wide-ranging conversation on the evolving relationship between wellness and longevity—and why these two frameworks must converge for both to remain meaningful. Drawing on decades of experience across hospitality, spa, and integrative health, Anna shares a global lens on everything from Blue Zones and wearables to the spiritual dimensions of aging well. She also addresses the growing risk of “longevity washing,” and how practitioners can maintain integrity in a rapidly commercializing sector. This episode also features GWI's Beth McGroarty, who highlights the explosive growth of longevity clinics and destination resorts worldwide, and offers a critical look at the biohacking industry’s rush to rebrand itself as “longevity.” Expanded Talking Points: Wellness vs. longevity: What’s the difference—and why does it matter?How the spa and hospitality industries are adopting diagnostics, neurotech, and longevity labsWhy purpose, joy, and spiritual health must sit alongside biomarkers and senolyticsAnna’s wearable strategy: seasonally intentional tech use + embodied self-awarenessBeth McGroarty: Global boom in longevity clinics, how legacy wellness brands are expanding into medicalized models, and the red flags of longevity-branded recovery therapiesThe need for regulatory clarity around treatments like IV drips, cryo, and hyperbaric chambersResources: Global Wellness Institute (GWI)Anna Bjurstam Bio & ProjectsMentioned book: Lifespan by David SinclairHosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors To learn more about the GWI please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

The longevity industry is no longer a niche—it’s a global economic force. In this episode, Alexia Brue speaks with Phil Newman, founder of Longevity.Technology, about how aging science is evolving from the lab into commercial markets. From diagnostics and AI to digital therapeutics and cellular reprogramming, Phil offers a macro view of where capital is flowing, which technologies are gaining traction, and why “healthspan” is the true opportunity of our time. Inside this episode, learn: How longevity evolved from fringe science to a trillion-dollar opportunity Why healthspan—not just lifespan—will define the next decade Why longevity clinics are the new bridge between wellness and clinical care The 25 sub-domains tracked by Longevity.Technology (e.g. epigenetics, AI diagnostics) What investors, entrepreneurs, and policymakers need to understand about this fast-moving sectorResources Mentioned: Longevity.Technology To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.  Produced by: Emily Roberts and Ali Alquiza of Over Lunch  Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors Music provided by: Myndstream     Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more. Subscribe, rate, & review wherever you listen to podcasts! 

What if aging was optional? In this kickoff episode, physician, futurist, and entrepreneur Dr. Peter Diamandis joins host Alexia Brue to unpack the technologies fueling what he calls the “healthspan revolution.” From full-body diagnostics and AI-powered imaging to muscle-centric medicine and regenerative therapies, Diamandis outlines a near-future where living to 100 in vibrant health is not only possible—but increasingly plausible. He shares his own daily protocol, breaks down longevity escape velocity, and introduces listeners to the $101M Healthspan X Prize. This episode also features insight from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute, who explores how longevity has rapidly overtaken wellness in the cultural zeitgeist and explains why the convergence of biotech and wellness is both revolutionary and in urgent need of regulation. Expanded Talking Points: What “longevity escape velocity” means—and why some believe it will arrive by 2030Peter’s personal protocol: sleep, supplements, training, and mindsetWhy muscle is a longevity organ and how to train for itHow full-body MRIs, CTs, and genome sequencing are redefining preventive careThe $101M Healthspan X Prize and the future of regenerative medicineBeth McGroarty: The rapid rise of longevity as a cultural movement, the pitfalls of “longevity washing,” and how the public’s appetite for deep scientific content is reshaping consumer educationResources Mentioned: Peter’s newsletter + blogThe Longevity GuidebookFountain LifeXPrize: HealthspanGlobal Wellness InstituteTo learn more about the Global Wellness Institute please visit us at globalwellnessinstitute.org, connect with us on Instagram and subscribe to our YouTube channel.  This podcast is produced by Emily Roberts and Ali Alquiza of Over Lunch.  This podcast is hosted by Alexia Brue, co-founder of Well+Good, and founder of a healthspan training studio; learn more at The Practice.  Music provided by Myndstream.    Subscribe, rate,& review wherever you listen to podcasts! 

The Wellness Roundtable: Longevity is a podcast about the science and strategy of living longer—and better. Hosted by Well+Good co-founder Alexia Brue and produced by the Global Wellness Institute, this 10-episode series convenes top minds in longevity: scientists, CEOs, investors, and disruptors shaping the emerging healthspan economy. From biomarkers and AI to exercise, nutrition, and regenerative medicine, each episode unpacks what’s real, what’s next, and what matters. Smart, surprising, and grounded in GWI’s global research, this is the longevity conversation the wellness world has been waiting for. To learn more about the Global Wellness Institute please visit us at globalwellnessinstitute.org, connect with us on Instagram and subscribe to our YouTube channel.  This podcast is produced by Emily Roberts and Ali Alquiza of Over Lunch.  This podcast is hosted by Alexia Brue, co-founder of Well+Good, and founder of a healthspan training studio; learn more at The Practice.  Music is provided by Myndstream. Subscribe, rate, &  review wherever you listen to podcasts!